our projects
MAP-GLIOMA
Imaging Mass Cytometry to spAtially resolve the tumour microenvironment of Pediatric-type diffuse high-grade Gliomas
About the MAP-GLIOMA project
Project MAP-GLIOMA utilises spatial biology to examine tumour samples in their natural state, preserving important characteristics often lost during traditional analysis methods.
In particular, Imaging Mass Cytometry (IMC) is an advanced technology that allows researchers to visualise how individual cells within a tumour interact with their environment and to study the expression of multiple proteins in brain tumour samples at the single-cell level.
The project focuses on pediatric-type diffuse high-grade gliomas, which are aggressive brain tumours. The goal is to develop specific protocols and expand current antibody panels to investigate the heterogeneous cell types within these tumours and their surrounding environments. By employing IMC, the team will create a detailed map of the tumour's cellular composition, marker expression, and cellular interaction networks. This work aims to enhance diagnostic and treatment options for children affected by these devastating tumours.
About Ospedale Pediatrico Bambino Gesù
Ospedale Pediatrico Bambino Gesù is a tertiary care academic children's hospital located in Rome that is under extraterritorial jurisdiction of the Holy See. As a tertiary children referral centre, the hospital provides over 20 specialties of healthcare through 10 pediatric departments.
